Quantitative Analysis of
Diffusion and Chemical Reaction in
Pressure-Driven Microfluidic Channels
TABLE OF CONTENTS
Chapter 1: Background of Microfluidics
1.1 Types of Fluid Actuation
1.1.1 Devices using Pressure-Driven Flow
1.1.1.1 Flow Injection Analysis
1.1.1.2 Field-Flow Fractionation
1.1.1.3 The T-sensor
1.1.2 Devices using Electrokinetic
Pumping
1.2 Materials
1.2.1 Silicon and Glass
1.2.2 Plastics
1.2.3 Elastomer
1.3 Major Microfluidic Applications
1.3.1 Sample Preparation and Handling
1.3.2 Chemical and Biological Detection
1.3.3 Proteomics
1.3.4 DNA Microarrays
1.3.5 Microreactors
1.4 Quantification Methods in the T-sensor
Chapter 2: Experimental Setup
2.1 Device Fabrication
2.2 Fluid Handling
2.3 Microscopy and Data Collection
2.4 Data Analysis
Chapter 3: Custom-coded Mathematical Models
3.1 Scope of Models
3.2 One-dimensional Model
3.3 Two-dimensional Model
3.4 Model Validation
3.5 Comparison of One- and Two-dimensional Models
3.6 Comments on Flow Development and Entry Length
Chapter 4: Microfluidic Assay for Human Serum Albumin
4.1 Statement of Purpose and Goals
4.2 Characterization of Molecular System
4.3 Experimental Protocol
4.4 Results and Discussion
4.5 Conclusions
Chapter 5: Theoretical Studies on Molecular Diffusion
5.1 Statement of Purpose
5.2 Methods
5.2.1 Studies on Accuracy of Diffusion
Coefficient Measurement
5.2.2 Studies on Diffusive Scaling Laws
5.3 Results
5.3 1 Analysis of Accuracy of Diffusion
Coefficient Measurement
5.3.2 Analysis of Studies on Diffusive Scaling Laws
5.4 Implications on Experimental Studies
Chapter 6: Diffusion Coefficient Measurements
6.1 Statement of Purpose
6.2 Experimental Protocol
6.3 Results and Discussion
6.4 Conclusions
Chapter 7: An Enzyme-based Microfluidic Assay
7.1 Statement of Purpose
7.2 Range of Potential Assays
7.3 Characterization of Molecular System
7.4 Experimental Protocol
7.5 Data Collection and Analysis
7.6 Results and Discussion
7.7 Conclusions
Chapter 8: Summary of Other Work
8.1 Diffusion Immunoassay
8.2 A Ferrofluidic Magnetic Micropump
8.3 Photobleaching in Microchannels
8.4 Sedimentation in Microchannels
8.5 Absorption-enhanced Field Flow Fractionation
List of References
Appendix A:
|
Quantitative Analysis of
Molecular Interaction in a Microfluidic Channel: The T-sensor |
Appendix B:
|
Theoretical Analysis of
Molecular Diffusion in Pressure-Driven Laminar Flow in Microfluidic
Channels |
| Appendix C: |
Optical Measurement of
Transverse Molecular Diffusion in a Microchannel |
| Appendix D: |
Theoretical Analysis of
Diffusive Scaling Laws in a Pressure-Driven Microfluidic Channel |
| Appendix E: |
Modeling an Enzyme Reaction in
the T-sensor |
| Appendix F: |
A Rapid Diffusion Immunoassay in
a T-Sensor |
Appendix G:
|
A Ferrofluidic Magnetic Micropump |
| Appendix H: |
Code for One-dimensional model |
| Appendix I: |
Flow Chart for Two-dimensional
Model |
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